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Friday, June 23rd, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Chelerythrine Attenuates Renal Ischemia/Reperfusion-induced Myocardial Injury by Activating CSE/H2S via PKC/NF-κB Pathway in Diabetic Rats.

PubMed

 

Resource

Kidney & blood pressure research 2017 18; 42(2)

Authors

Hu B1; Xu G2; Zheng Y3; Tong F4; Qian P5; Pan X6; Zhou X7; Shen R8;

Author Information
  • 1Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, China.
  • 2Department of Pathology and Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China.
  • 3Department of Pathology and Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China.
  • 4Department of Pathology and Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China.
  • 5Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, China.
  • 6Department of Pathology and Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China.
  • 7Department of Pathology and Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China.
  • 8Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University Affiliated TCM Hospital, Jiaxing, China.

Abstract

BACKGROUND/AIMS: Chelerythrine (CHE), a benzophenanthridine alkaloid, is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. The purpose of the present study was to evaluate the effect of CHE on myocardial recovery after renal ischemia/reperfusion (I/R)-induced myocardial injury (RI/RMI) in a streptozocin (STZ)-induced diabetic rat model.

METHODS: Diabetes mellitus (DM) rats preconditioned with CHE and D, L-propargylglycine (PAG) were subjected to renal I/R. The extent of cardiac morphologic lesions and the biochemical markers of cardiorenal function and oxidative stress were detected utilizing hematoxylin-eosin staining, commercial kits, and enzyme-linked immunoassay, respectively. The expressions of cystathionine-γ-lyase (CSE), PKC-α, PKC-β2, and nuclear factor-kappa B (NF-κB) in the rat myocardial tissue were measured utilizing western blotting.

RESULTS: Renal I/R treatment resulted in myocardial injury. CHE-preconditioning promoted the recovery from myocardial damage by ameliorating the biochemical parameters of myocardial injury, reducing oxidative stress, increasing the H2S level, up-regulating the expression of CSE, and down-regulating the expressions of PKC-α, PKC-β2, and NF-κB.

CONCLUSION: These findings suggest that CHE-pretreatment may exert a protective effect on the myocardium against RI/RMI by activating endogenous CSE/H2S via PKC/NF-κB pathway in STZ-induced diabetic rats. Further studies are needed defining underlying mechanisms.

© 2017 The Author(s). Published by S. Karger AG, Basel.

PMID

28624831

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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