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How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?




GeroScience 2017 Jun 18; ()


Aiello AE1; Chiu YL2; Frasca D3;

Author Information
  • 1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • 2Department of Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
  • 3Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Room #3146A, P.O. Box 016960 (R-138), Miami, FL, 33101, USA. dfrasca@med.miami.edu.


Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.




Publication Type: Journal Article, Review

This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.

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