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Thursday, September 14th, 2017
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Characterization of social cognition impairment in multiple sclerosis.

PubMed

 

Resource

European journal of neurology 2017 Sep 12; ()

Authors

Neuhaus M1; Bagutti S2; Yaldizli Ö3; Zwahlen D4; Schaub S5; Frey B6; Fischer-Barnicol B7; Burgunder JM8; Martory MD9; Pöttgen J10; Annoni JM11; Penner IK12;

Author Information
  • 1Neurology Unit, University of Fribourg, Switzerland.
  • 2Neurology Unit, University of Fribourg, Switzerland.
  • 3Department of Neurology, University Hospital Basel, Switzerland.
  • 4Department of Cognitive Psychology, University of Basel, Switzerland.
  • 5Department of Cognitive Psychology, University of Basel, Switzerland.
  • 6Department of Neurology, University Hospital Berne, Switzerland.
  • 7Department of Neurology, University Hospital Basel, Switzerland.
  • 8Department of Neurology, University Hospital Berne, Switzerland.
  • 9Neuropsychology Unit, University Hospital of Geneva, Switzerland.
  • 10Institut für Neuroimmunologie und Multiple Sklerose, Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Deutschland.
  • 11Neurology Unit, University of Fribourg, Switzerland.
  • 12Cogito Center for Applied Neurocognition and Neuropsychological Research and Department of Neurology, University Hospital Düsseldorf, Germany.

Abstract

BACKGROUND: Multiple sclerosis (MS) has been associated with deficits in social cognition. However, little is known about which domains of social cognition are predominantly affected and what other factors are associated with it.

OBJECTIVES: 1) To characterize social cognition deficit in a group of MS outpatients. 2) To relate impairment in social cognition to overall cognitive status, depression and fatigue.

METHODS: Thirty-five MS patients (mean disease duration 12.9 years, median EDSS 3) and thirty-four healthy controls (HCs) were examined using the German version of the Geneva Social Cognition Scale to measure different domains of social cognition. Standard neuropsychological testing was applied to all patients and to 20 HCs. Patient-reported outcomes included questionnaires for fatigue, depression, anxiety and executive-behavioural disturbances.

RESULTS: The mean social cognition raw score was lower in the MS patients compared to the HCs (86.5±8.7 vs. 91.2±5.9 p=0.005; d=0.6) and did not correlate with EDSS or disease duration. The difference was driven by facial affect recognition and the understanding of complex social situations (14% and 23% of patients under the cut-off, respectively). The impairment in these two tasks did not correlate with general cognitive performance or depression but with fatigue.

CONCLUSIONS: The impairment in our group was restricted to high order and affective social cognition tasks and independent of general cognitive performance, EDSS, disease duration and depression. Fatigue correlated with social cognition performance, which might be due to common underlying neuronal networks. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

PMID

28898535

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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