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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.

PubMed

 

Resource

Biochemical and biophysical research communications Feb ; ()

Authors

Xie T1; Li X2; Ye F3; Lu C4; Huang H5; Wang F6; Cao X7; Zhong C8;

Author Information
  • 1Department of Thoracic and Cardiovascular Surgery, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 2Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 3Department of Thoracic Surgery, Affiliated Haian Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 4Department of Thoracic and Cardiovascular Surgery, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 5Department of Thoracic and Cardiovascular Surgery, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 6Department of Thoracic and Cardiovascular Surgery, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China.
  • 7Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu, 226001, PR China. Electronic address: caoxiaoleigzf@163.com.
  • 8Department of Thoracic and Cardiovascular Surgery, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, PR China. Electronic address: zhongcjnt001@126.com.

Abstract

The Kinesin family member 2a (KIF2A), that belongs to the Kinesin-13 microtubule depolymerases, plays an important role in cancer cell proliferation, migration and apoptosis in various types of cancer such as gastric cancer, breast cancer, and squamous cell carcinoma of the oral tongue, but, its role and mechanism in lung adenocarcinoma (LUAD) is largely unknown. The present study reported that KIF2A was overexpressed in LUAD tissues as compared with adjacent normal tissues. KIF2A was closely correlated with TNM stage and lymph node metastasis (P < 0.01), whereas, no similar relationships between KIF2A and age, gender, smoking and differentiation. Multivariate analysis indicated that hyperexpression of KIF2A in LUAD was an independent risk factor for worse overall survival in LUAD patients (HR: 3.135, 95%CI: 1.331-7.112, p < 0.05). In vitro, KIF2A knockdown markedly reduced epithelial-mesenchymal transition and LUAD cell A549 migration. Furthermore, silencing KIF2A inhibited cell proliferation and induced apoptosis in lung adenocarcinoma(LUAD) cells. In conclusion, KIF2A may serve as a valuable prognostic indicator and promising therapeutic target of LUAD.

Copyright © 2018. Published by Elsevier Inc.

PMID

29427669

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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