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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Pregnancy Outcomes in Women with an Early Diagnosis of Gestational Diabetes Mellitus.

PubMed

 

Resource

Diabetes research and clinical practice Feb ; ()

Authors

Feghali MN1; Abebe KZ2; Comer DM3; Caritis S4; Catov JM5; Scifres CM6;

Author Information
  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine. Electronic address: maisafeghali@gmail.com.
  • 2Department of Medicine, University of Pittsburgh School of Medicine.
  • 3Department of Medicine, University of Pittsburgh School of Medicine.
  • 4Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine.
  • 5Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine.
  • 6Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine; Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine.

Abstract

AIM: To examine pregnancy outcomes in women with gestational diabetes mellitus (GDM) based on the timing of diagnosis.

METHOD: We compared demographics, blood sugars and outcomes between women diagnosed before (n=167) or after 24 weeks' gestation (n=1202) in a single hospital between 2009 and 2012. Because early screening is risk-based we used propensity score modelling and conditional logistic regression to account for systematic differences.

RESULTS: Women diagnosed with GDM before 24 weeks were more likely to be obese and they were less likely to have excess gestational weight gain (35 vs. 45%, p=0.04). Early diagnosis was associated with more frequent therapy including glyburide (65 vs. 56%, p<0.001) and insulin (19 vs 6%, p<0.001). After propensity score modelling and accounting for covariates, early diagnosis was associated with an increased risk for macrosomia (OR 2, 95% 1-4.15, p=0.0498). Early diagnosis was not associated with other adverse outcomes. In a subgroup analysis comparing women treated with glyburide prior to 24 weeks compared to those diagnosed after 24 weeks, early diagnosis in women treated with glyburide was associated with an increased risk for macrosomia (OR 2.3, 95% CI 1.1-5.4, P=0.04).

CONCLUSION: Women diagnosed with GDM before 24 weeks have unique features, are at risk for adverse outcomes, and require targeted approaches to therapy.

Copyright © 2018. Published by Elsevier B.V.

PMID

29427694

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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