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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

PubMed

 

Resource

Neurobiology of disease Feb ; ()

Authors

Salas IH1; Weerasekera A2; Ahmed T3; Callaerts-Vegh Z4; Himmelreich U5; D'Hooge R6; Balschun D7; Saido TC8; De Strooper B9; Dotti CG10;

Author Information
  • 1VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven Department for Neurosciences, Leuven Institute for Neurodegenerative Disorders (LIND), KU Leuven, Leuven, Belgium.
  • 2Biomedical MRI-Unit/MoSAIC, KU Leuven Campus Gasthuisberg, Leuven, Belgium.
  • 3Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium; Neurological Disorders Research Center, Doha, Qatar.
  • 4Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium.
  • 5Biomedical MRI-Unit/MoSAIC, KU Leuven Campus Gasthuisberg, Leuven, Belgium.
  • 6Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium.
  • 7Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium.
  • 8Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, Japan.
  • 9VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven Department for Neurosciences, Leuven Institute for Neurodegenerative Disorders (LIND), KU Leuven, Leuven, Belgium; UK Dementia Research Institute (DRI-UK), ION UCL, London, UK. Electronic address: bart.destrooper@kuleuven.vib.be.
  • 10Centro de Biologıa Molecular 'Severo Ochoa' (CSIC/UAM), Madrid, Spain. Electronic address: cdotti@cbm.csic.es.

Abstract

Type 2 diabetes (T2DM) and obesity might increase the risk for AD by 2-fold. Different attempts to model the effect of diet-induced diabetes on AD pathology in transgenic animal models, resulted in opposite conclusions. Here, we used a novel knock-in mouse model for AD, which, differently from other models, does not overexpress any proteins. Long-term high fat diet treatment triggers a reduction in hippocampal N-acetyl-aspartate/myo-inositol metabolites ratio and impairs long term potentiation in hippocampal acute slices. Interestingly, these alterations do not correlate with changes in the core neuropathological features of AD, i.e. amyloidosis and Tau hyperphosphorylation. The data suggest that AD phenotypes associated with high fat diet treatment seen in other models for AD might be exacerbated because of the overexpressing systems used to study the effects of familial AD mutations. Our work supports the increasing insight that knock-in mice might be more relevant models to study the link between metabolic disorders and AD.

Copyright © 2017. Published by Elsevier Inc.

PMID

29427755

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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