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Monday, February 12th, 2018
Table of Contents

1 Introduction
5 PMID
 [F] Diseases Research  / PubMed Research Articles  /
Gout drugs use and risk of cancer: A case-control study.

PubMed

 

Resource

Joint, bone, spine : revue du rhumatisme Feb ; ()

Authors

Yang HC1; Nguyen PAA2; Islam MM3; Huang CW4; Poly TN5; Iqbal U6; Jack Li YC7;

Author Information
  • 1College of Medicine Science and Technology, Taipei Medical University, Taipei 110, Taiwan; International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan.
  • 2International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan; Department of Population and Quantitative Health Sciences, Case Western Reserve University, United states.
  • 3International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan; Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan.
  • 4Joint Commission of Taiwan, New Taipei City 110, Taiwan.
  • 5International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan; Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan.
  • 6International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan; Master's Program in Global Health and Development Department, College of Public Health, Taipei Medical University, Taipei 110, Taiwan.
  • 7College of Medicine Science and Technology, Taipei Medical University, Taipei 110, Taiwan; International Center for Health Information Technology, Taipei Medical University, Taipei 110, Taiwan; Department of Dermatology, Taipei Medical University - Wan Fang Hospital, Taipei 110, Taiwan. Electronic address: jack@tmu.edu.tw.

Abstract

OBJECTIVE: Firm conclusion about whether short and long-term gout medications use has an impact on cancer risk remain inconclusive. The aim of this study was to investigate the association between gout drugs use and risk of cancer.

METHODS: We conducted a retrospective longitudinal population-based case-control study in Taiwan. Cases were identified all patients who were aged 20 years or above, and had a first time diagnosis of cancers for the period between 2001 and 2011. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were calculated by using conditional logistic regression.

RESULTS: We examined 601,733 cases and 2,406,932 matched controls. The adjusted odd ratio for any gout drugs use and overall cancer risk was 1.007 (95% CI, 0.994 -1.020). There was a significant risk of leukemia (AOR: 1.34, 95%CI 1.20-1.50), endometrial cancer (AOR: 1.33, 95%CI 1.12-1.57), non-Hodgkin's (AOR: 1.24, 95%CI 1.13-1.35), female breast cancer (AOR: 1.21, 95%CI 1.13-1.29), cervical cancer (AOR: 1.21, 95%CI 1.07-1.37). However, no association was observed in male group (AOR: 0.97, 95%CI 0.95-0.98) but female showed a significantly increased risk of cancer at any site (AOR: 1.107, 95%CI 1.08-1.13).

CONCLUSION: In summary, our results suggest that gout drugs increase risk of the most common cancers, particularly in leukemia, non-Hodgkin's, endometrial, breast and cervical cancer.

Copyright © 2018. Published by Elsevier SAS.

PMID

29427783

Others

Publication Type: Journal Article


This article is licensed under the the National Library of Medicine License. It uses material from the PubMed National Library of Medicine Data.


Last Modified:   2016-03-27


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