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March 26, 2016
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1 Introduction
Mammary tumor



A mammary tumor is a tumor originating in the mammary gland. It is a common finding in older female dogs and cats that are not spay ed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to the groin on both sides of the midline. There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy , and treatment options. The prevalence in dogs is about three times that of women.


Female dogs who are not spayed or who are spayed later than the first heat cycle are more likely to develop mammary tumors. Specifically, dogs spayed before their first heat have 0.5 percent the risk of intact female dogs, and dogs spayed after just one heat cycle have 8 percent the risk. Obesity at one year of age and eating red meat have also been associated with an increased risk for these tumors, as has the feeding of high fat homemade diets.


Historically, about 50 percent of mammary tumors in dogs were found to be malignant, although taking into account tumor behavior, one study has estimated true malignancy in mammary tumors to be 21 to 22 percent. Inflammatory carcinomas describe tumors that are fast growing and have bruising, edema, and pain, and can also cause disseminated intravascular coagulation. They are the most malignant type of canine mammary tumor.

Malignant tumors are also subdivided histopathologically into those showing blood vessel wall invasion and those that do not. Without blood vessel wall invasion there is a better prognosis. Tumor type is also important. Sarcomas and carcinosarcomas carry an average survival time of nine to twelve months.

Diagnosis and treatment

Appearance and location of the tumor is enough to identify it as a mammary tumor. Biopsy will give type and invasiveness of the tumor. Surgical removal is the treatment of choice, but chest x-rays should be taken first to rule out metastasis. Removal should be with wide margins to prevent recurrence, taking the whole mammary gland if necessary. Because 40 to 50 percent of dog mammary tumors have estrogen receptors,

Breeds at increased risk

  • Poodle

  • Brittany Spaniel

  • English Setter

  • Pointer

  • Fox Terrier

  • Boston Terrier

  • Cocker Spaniel

  • lhasa apso

Mammary tumors are the third most common neoplasia in cats, following lymphoid and skin cancers. The incidence of mammary tumors in cats is reduced by 91 percent in cats spayed prior to six months of age and by 86 percent in cats spayed prior to one year, according to one study. Siamese cats and Japanese breeds seem to have increased risk, and obesity also appears to be a factor in tumor development. Malignant tumors make up 80 to 96 percent of mammary tumors in cats, almost all adenocarcinomas. Male cats may also develop mammary adenocarcinoma, albeit rarely, and the clinical course is similar to female cats. As in dogs, tumor size is an important prognostic factor, although for tumors less than three centimeters the individual size is less predictive. According to one study, cats with tumors less than three cm had an average survival time of 21 months, and cats with tumors greater than three cm had an average survival of 12 months. Metastasis tends to be to the lungs and lymph nodes, and rarely to bone. Diagnosis and treatment is similar to the dog. There is a better prognosis with bilateral radical surgery (removing the both mammary chains) than with more conservative surgery. Doxorubicin has shown some promise in treatment.

Mammary tumors in ferrets

Mammary tumors are rare in ferrets. Appearance tends to be a soft, dark colored lump. Most seem to be benign and occur most frequently in neutered males. Surgery is recommended.

Mammary tumors in guinea pigs

Mammary tumors in guinea pigs occur in males and females. Most are benign, but 30 percent are adenocarcinomas. They usually do not metastasize, but aggressive surgery is necessary to prevent recurrence.

Mammary tumors in mice

Most mammary tumors in mice are adenocarcinomas. They can be caused by viral infection. A well known tumor virus of the mouse is the mouse mammary tumor virus MMTV, which may be the most common cause of this tumor in mice.

Mammary tumors in rats

Most mammary tumors in rats are benign fibroadenomas, which are also the most common tumor in the rat. Less than 10 percent are adenocarcinomas. There is a good prognosis with surgery. Spayed rats have a decreased risk of developing mammary tumors.

Researchers at the University of Wisconsin???Madison have found that lavender oil may have played a role in the reduction of advanced mammary tumors in lab rats. Research is on-going for potential breast , ovarian , pancreatic , liver , and prostate cancer treatments in humans.

Mammary tumors in hamsters and gerbils

Mammary tumors tend to be benign in hamsters and malignant in gerbils.

Mammary tumors in hedgehogs

Mammary gland adenocarcinoma is the most common tumor of the hedgehog.

External links

  • Mammary Tumors in Dogs from Pet Cancer Center

  • Mammary Tumors in Cats from Pet Cancer Center

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mammary tumor".

Last Modified:   2010-11-25

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